Cyp24a1酶
WebJan 14, 2015 · 細胞色素 P450 24A1(英語: Cytochrome P450 24A1 ,縮寫CYP24A1)也被稱為維生素D 3 24-羥化酶( Vitamin D3 24-hydroxylase ,EC 1.14.15.16),是細胞 … WebJan 1, 2024 · CYP24A1 is a mitochondrial inner-membrane cytochrome P450 enzyme that exhibits multifunctionality: it is able to hydroxylate both the C23 or the C24 side-chain …
Cyp24a1酶
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WebMar 1, 2012 · Mutations of the CYP24A1 gene, which encodes the 1,25-dihydroxyvitamin D-24-hydroxylase cytochrome P450, Cyp24A1, are predicted to result in elevated 1,25-dihydroxyvitamin D concentrations, hypercalcemia, hypercalciuria, nephrolithiasis, and bone disease. Treatment of hypercalcemia associated with CYP24A1 gene mutations has not … WebJan 14, 2015 · NX_Q07973 - CYP24A1 - 1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial - Function. A cytochrome P450 monooxygenase with a key role in vitamin D catabolism and calcium homeostasis. Via C24- and C23-oxidation pathways, catalyzes the inactivation of both the vitamin D precursor calcidiol (25-hydroxyvitamin D(3)) and the …
WebCYP24A1, encoding the vitamin D-24-hydroxylase, is of major clinical and physiologic importance, serving to regulate the catabolism of 1,25-(OH) 2 D, the physiologically … CYP24A1 is expressed in tissues which are considered targets for vitamin D, including kidney, intestine and bone. Transcription of the CYP24A1 gene is markedly inducible by 1,25-(OH)2D3 binding to the vitamin D receptor. The gene has a strong, positive vitamin D response element in the promoter. Through regulation of CYP24A1 expression, a negative feedback control system is created to limit the effects of 1,25-(OH)2D3.
WebMay 30, 2024 · 大鼠1,25-二羟*(3)24-羟化酶,线粒体(cyp24a1)elisa试剂盒 ... 有限公司成立于上海,在上海张江高科园区拥有独立实验室,公司主力提供的生化产品有:酶联免疫试剂盒(elisa试剂盒)、标准品、对照品、抗体、生化试剂、培养基、血清、细胞株、金标试 … WebLoss of function mutations in the CYP24A1 gene have been shown to lead to insufficient deactivation of bioactive vitamin D metabolites, resulting in a phenotype characterized by suppressed serum parathyroid hormone (PTH), increased serum 1,25-dihydroxyvitamin D (DHVD) concentrations, hypercalcemia, and hypercalciuria or nephrolithiasis.
WebJun 16, 2024 · Fluconazole has been successfully reported to reduce calciuria in patients with CYP24A1 or SLC34A3 mutations, with no safety warnings. Thus, based on these case reports, we hypothesize that fluconazole is effective to decrease and normalize calciuria in patients with hypercalciuria and increased 1,25(OH)2D levels. The FLUCOLITH trial is a ...
WebApr 12, 2024 · 3-羟基3-甲基戊二酰辅酶A还原酶(HMGCR)重组蛋白说明书. Recombinant 3-Hydroxy-3-Methylglutaryl Coenzyme A Reductase (HMGCR) [ PROPERTIES ] Source: Prokaryotic expression. Host: E. coli. Residues: Ala638~Ala887. Tags: N-terminal His-Tag. Subcellular Location: Endoplasmic reticulum membrane; Multi-pass membrane. protein. … grand haven south beachWeb细胞色素 P450 24A1(英語: Cytochrome P450 24A1 ,缩写CYP24A1)也被称为维生素D 3 24-羟化酶( Vitamin D3 24-hydroxylase ,EC 1.14.15.16),是细胞色素P450超家族 … grand haven spectrum health labWeb1.cyp1a2抑制剂:cyp1a2抑制剂主要有抗抑郁药 氟伏沙明、喹诺酮类抗生素及非选择性的肝药酶抑制剂西咪替丁等,因茶碱、华法林、咖啡因等药物安全性较低,药酶抑制剂可使 … grand haven south pierhead lighthouseWebPROTEIN SUMMARY SECTION OVERVIEW RNA DATA ANTIBODY DATA. CYP24A1 INFORMATION. Proteini. Full gene name according to HGNC. Cytochrome P450 family 24 subfamily A member 1. Gene namei. Official gene symbol, which is typically a short form of the gene name, according to HGNC. CYP24A1 (CP24, CYP24, P450-CC24) Protein classi. chinese embassy in czechiaWebCYP24A1 rs1570669 was linked to a reduced risk of stroke, and rs6068816 could increase susceptibility to is-chemic stroke [12]. Five common variants of CYP24A1 were reportedly related to cancer risks, including pros-tate, breast, colon and pancreatic cancers [13]. Neverthe-less, the linkage between CYP24A1 genetic variants and chinese embassy in boston maWeb細胞色素 P450 24A1(英語:Cytochrome P450 24A1,縮寫CYP24A1)也被稱為維生素D3 24-羥化酶(Vitamin D3 24-hydroxylase,EC 1.14.15.16),是細胞色素P450超家族的一 … chinese embassy in bucharestWebThe number of cysts ≥5 mm in size was above the 97.5th percentile of an age- and sex-matched control population in 55% and 67% of patients with confirmed and suspected pathogenic variants, respectively. At least 1 cyst (≥5 mm in size) was found in 80% of children with confirmed CYP24A1 deficiency. Conclusions: These observations strongly ... chinese embassy in canada