Cisplatin alkylating agent

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August undefined, 2024

WebDec 19, 2011 · Alkylating agents Cause DNA cross-links and prevent cell replication ... The platinum-based chemotherapy agents cisplatin, carboplatin, and oxaliplatin, used to treat a huge number of cancers including the lung, upper and lower GI, ovarian, and germ cell tumours, are a common cause of renal tubular and glomerular damage, which can be … Some of the substances require conversion into active substances in vivo (e.g., cyclophosphamide). Cyclophosphamide is one of the most potent immunosuppressive substances. In small dosages, it is very efficient in the therapy of systemic lupus erythematosus, autoimmune hemolytic anemia, granulomatosis with polyangiitis, and other autoimmune diseases. High dosages cause pancytop…

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WebCisplatin is another alkylating agent that is used to treat lung cancer, as well as other types of cancer including testicular, ovarian, bladder, head and neck, esophageal, breast, cervical, stomach, and prostate cancers. Cisplatin is also used in the treatment of lymphomas, neuroblastoma, sarcomas, multiple myeloma, melanoma, and mesothelioma. WebCisplatin is classified as an alkylating agent. Alkylating agents are most active in the resting phase of the cell. These drugs are cell cycle non-specific. Note: We strongly … dwyryd estuary

Cisplatin - Wikipedia

WebCisplatin is similar to the bifunctional alkylating agents. It covalently binds to DNA and disrupts DNA function. 6. After cisplatin enters the cells, the chloride ligands are … Cisplatin is a chemotherapy medication used to treat a number of cancers. These include testicular cancer, ovarian cancer, cervical cancer, bladder cancer, head and neck cancer, esophageal cancer, lung cancer, mesothelioma, brain tumors and neuroblastoma. It is given by injection into a vein. Common side effects include bone marrow suppression, hearing problems, incl… Webas with the alkylating agents. Cisplatin is used to treat a lot of different cancers, including lung, testicular, and ovarian cancer. The risk of leukemia rises as the amount of drug … crystalmeth urine

Cisplatin: Uses, Interactions, Mechanism of Action - DrugBank

The Mechanism of Action of Alkylating Agents Cancer Research ...

WebPlatinum compounds. The platinum compounds are largely used in the treatment of lung, breast, ovarian, and colon cancers. The chemotherapeutic mechanism of platinum compounds is typical of DNA-binding alkylating agents. If the DNA damage exceeds the ability of the cell to repair, the cell undergoes apoptotic cell death. WebSep 15, 2024 · Cisplatin is the prototype platinum coordination complex classified as an alkylating agent and used intravenously in the treatment of several forms of … crystal meth treatment methodsWebthe agent leaks outside the vein.15,17 A vesicant (Box 1) is any drug that has the potential to cause tissue damage when leakage occurs outside the vein.13 Box 1 Examples of Vesicant Chemotherapy Agents Alkylating agents: DNA binding • Nitrogen mustard Anthracyclines: DNA binding • Daunorubicin • Doxorubicin • Epirubicin • Idarubicin crystal meth treatment options

"WebCisplatin is a platinum-based agent whose nephrotoxicity is thought related to the chloride in the cis position. Cisplatin gains entry into tubular cells via uptake by the OCT-2 … " - Cisplatin alkylating agent

Cisplatin alkylating agent

WebMar 10, 2015 · The alkylating agents are generally separated into six classes: (1) The nitrogen mustards [mechlorethamine, cyclophosphamide, ifosfamide, melphalan and chlorambucil] 2. Ethylenamine and … WebSep 15, 2024 · Mabs, the main cause of type 2 damage, are widely used in the management of many types of cancer. Chemotherapy agents that can cause reversible cardiotoxicity are trastuzumab, bevacizumab, lapatinib, and sunitinib. These agents also may cause hypertension. A decrease in vascular endothelial growth factor (VEGF) results in a …

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WebFor carboplatin and cisplatin, the first hypersensitivity reaction typically occurs around the second and third re-exposure during the second line of therapy (eighth and ninth courses overall). For oxaliplatin, the first hypersensitivity reaction can … WebNitrosoureas are a particular type of alkylating agent. Unlike other alkylating agents, nitrosoureas can travel into your brain and kill cancer cells there. Nitrosoureas are used to treat some brain tumors. Selected alkylating agents include: Altretamine. Bendamustine. Busulfan. Carboplatin. Chlorambucil. Cisplatin. Cyclophosphamide ...

WebNo correlation was found between the activity of the two enzymes and the sensitivity to alkylating agents of different structures such as CC-1065, tallimustine, dimethylsulphate (DMSO), N-methyl-N'-nitro-N-nitrosoguanidine (MNNG), cis-diamminedichloroplatinum (cDDP) and melphalan (L-PAM). ... Cisplatin / toxicity DNA Glycosylases* Distamycins ... http://www.bccancer.bc.ca/drug-database-site/Drug%20Index/Cisplatin_monograph.pdf

WebThe term “alkylating agent” has been defined and a detailed discussion made of the mechanisms (Sn1 and Sn2) by which they interact with nucleophilic centers. The various nucleophiles likely to be encountered in vivo are discussed in terms of their relative reactivities toward alkylating agents.

WebCisplatin; Cyclophosphamide; Dacarbazine; Ifosfamide; Lomustine; Mechlorethamine; Melphalan; Oxaliplatin; Temozolomide; Thiotepa; Trabectedin; Nitrosoureas. … crystalmeth tyler grossoWebNov 1, 2004 · The platinum coordination complexes (cisplatin, carboplatin, oxaliplatin) and most alkylating agents form strong electrophilic intermediates that act via nucleophilic substitution reactions to form inter- and intrastrand DNA crosslinks. crystal meth urine testWebDec 18, 2024 · Implications for Patient Care. Cisplatin is a platinum-based alkylating agent. It is labeled for use as a single agent for the treatment of advanced transitional cell bladder cancer, and in combination with other antineoplastic agents for the treatment of metastatic testicular cancer and metastatic ovarian cancer. [8,9,10] crystal meth ursachenWebCytostatic antibiotics of the anthracycline class are the best known of the chemotherapeutic agents that cause cardiotoxicity. Alkylating agents such as cyclophosphamide, ifosfamide, cisplatin, carmustine, busulfan, chlormethine and mitomycin have also been associated with cardiotoxicity. crystal meth use icd 10http://large.stanford.edu/courses/2012/ph241/ali1/docs/002043-pdf.pdf crystal meth tschechienWebThe three most active types of agents in the treatment of cancer of the ovary are platinum compounds (cisplatin or carboplatin), bifunctional alkylating agents … crystal meth tv showWebcisplatin decreases effects of cholera vaccine by immunosuppressive effects; risk of infection. Modify Therapy/Monitor Closely. Immunosuppressive therapies, including irradiation, antimetabolites, alkylating agents, cytotoxic drugs and corticosteroids (used in greater than physiologic doses), may reduce the immune response to cholera vaccine ... crystal meth users